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December 13, 2007

Laparoscopic nephroureterectomy for TCC of the ureter or renal pelvis

This review of an article by one of the founders of laparoscopic urology shows that with one of the common laparoscopic method to remove a kidney, ureter, and bladder cuff for transitional cell caner of the upper urinary tract lining there seems to be a higer recurrence rate and positive margins.

Our current technique is a robotic approach to remove the whole specimen intact with 2 robotic operations at the same setting. Prior to this I usually would remove the kidney with the laparoscope and then the ureter and bladder cuff with an open incision. Without robotic surgery, I never felt that I would obtain as good a specimen as with open surgery for the bladder part of the operation. With the robotic nephroureterectomy, I think the specimen is equal and there is no need to make a large incision or to open up the bladder like I did in open surgery.

clipped from www.urotoday.com
Oncologic Outcomes of Extravesical Stapling of Distal Ureter in Laparoscopic Nephroureterectomy
The local recurrence rate (17% vs. 0%) and the bladder recurrence rate (50% vs. 33%) were higher in the laparoscopic stapled group (p = 0.090)
Of note there were 3 patients (25%) with a positive margin in the laparoscopic group vs. none in the open group.
To be sure, as a frequent user of the stapler to remove the ureteral cuff, I have over the years altered my technique in order to improve removal of a larger cuff of bladder along with the entire ureteral tunnel:
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December 8, 2007

Testosterone and prostate size

Testosterone makes prostates grow larger and makes prostate cancer grow more quickly.

I came across a study that looks at prostate size and testosterone levels:

clipped from www.urotoday.com

Relationship between Serum Testosterone and Measures of Benign Prostatic Hyperplasia in Aging Men - Abstract
In our study, the serum testosterone levels in aging men did not correlate with the measures of BPH, including prostate volume and IPSS, regardless of whether total, free, or bioavailable testosterone was used. Age correlated with the measures of BPH, especially prostate volume. Additional large studies are needed to confirm these preliminary results.
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To my surprise, patients with higher testosterone levels did not have larger prostates. As expected, patients with higher PSAs and older patients had larger prostates.