IngentaConnect The incidence of high-grade prostatic intraepithelial neoplasia a...:

CONCLUSION:

Identifying multifocal HGPIN on first saturation biopsy is associated with an overall cancer detection rate of 80% on repeat 10-12-core biopsy. Although there were few patients, the detection of multifocal HGPIN warrants additional searches for concurrent invasive carcinoma by repeated biopsy.

The diagnosis of high grade PIN is an area that once required a repeat prostate biopsy. Recently, with an increase the number of biopsies that are done initially, there has been feelings that patients who only have high grade PIN do not need another biopsy. This article suggests that these patients should have a repeat biopsy. I believe follow-up with a PSA is a recent option in older patients with high grade PIN.